Mozzarella Pesto Chicken Grilled Cheese

Featured in: Everyday Family Meals

This mouthwatering grilled cheese combines juicy shredded chicken, vibrant basil pesto, and gooey mozzarella between toasted bread slices. With just 20 minutes of total time, it's an easy fusion sandwich perfect for lunch or dinner.

Layer pesto-spread bread with shredded chicken and mozzarella, butter the outsides, then cook in a skillet until golden and cheese melts. Optional additions like fresh tomato slices, basil leaves, and Parmesan elevate the flavors further.

Updated on Tue, 20 Jan 2026 15:24:00 GMT
The golden-brown Mozzarella Pesto Chicken Grilled Cheese rests on a cutting board, showcasing melted cheese and vibrant pesto. Pin this
The golden-brown Mozzarella Pesto Chicken Grilled Cheese rests on a cutting board, showcasing melted cheese and vibrant pesto. | platesignal.com

The smell of basil pesto hitting warm bread still takes me back to my tiny apartment kitchen, where I discovered that leftover rotisserie chicken and almost-empty cheese could become something magical. I'd been eating sad sandwiches for weeks until one rainy Tuesday, I decided to actually try combining the random ingredients in my fridge. The first bite made me laugh out loud—it was ridiculous how good it was. Now this sandwich has become my go-to whenever I want comfort food that feels a little fancy but takes almost no effort.

Last summer my sister came over exhausted from work and I made these for us at 9 PM. We stood at the counter eating them straight from the cutting board, too hungry to bother with plates, and she said it was exactly what she didnt know she needed. Thats the thing about this sandwich—it shows up when you need it most.

Ingredients

  • Sourdough or Italian bread: The sturdy texture holds everything together while getting perfectly crispy
  • Fresh mozzarella: Creates those irresistible cheese pulls we all live for
  • Unsalted butter: Softened butter spreads evenly for that golden exterior
  • Cooked shredded chicken breast: Rotisserie chicken works beautifully here
  • Basil pesto: The flavor engine that drives the whole sandwich
  • Parmesan cheese: Adds a salty umami punch
  • Tomato and fresh basil: Optional but highly recommended for brightness

Instructions

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Spread the pesto foundation:
Lay out your bread and spread that vibrant green pesto generously on two slices—this is where all the flavor starts.
Build the layers:
Pile on the shredded chicken followed by mozzarella slices letting them tumble naturally.
Add fresh elements:
Slide in tomato slices and tuck fresh basil leaves between the cheese layers.
Close it up:
Top with remaining bread slices and butter the exterior like you mean it.
Get that golden crunch:
Cook in a hot skillet 3 to 4 minutes per side until the bread turns deep golden and cheese starts oozing out the sides.
The waiting game:
Let rest one full minute before cutting—I learned this prevents all the cheese from escaping.
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Prep ingredients, rinse produce, and dry dishes efficiently with a built-in workstation designed for streamlined cooking.
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A close-up view of a Mozzarella Pesto Chicken Grilled Cheese, with gooey mozzarella stretching between slices of crusty bread. Pin this
A close-up view of a Mozzarella Pesto Chicken Grilled Cheese, with gooey mozzarella stretching between slices of crusty bread. | platesignal.com

My neighbor started requesting these whenever she had rough days at work. Something about warm melted cheese and familiar flavors just hits different.

Making It Your Own

Swap in provolone for mozzarella if you want a sharper bite or try different pestos like sun-dried tomato or spinach walnut. The formula works with whatever you have on hand.

The Bread Matters

Ciabatta creates a chewier texture while sourdough gives you that tangy crunch. Just avoid super soft sandwich bread which turns soggy under all these ingredients.

Perfect Pairings

A crisp white wine cuts through the richness or go with sparkling water and lemon for something lighter. A simple side salad makes it feel like a proper meal.

  • Use a grill pan if you want those professional looking panini lines
  • Let the butter reach room temperature for easier spreading
  • Cut diagonally for maximum satisfaction
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Keeps spoons and utensils off counters while cooking, catching drips and keeping your stovetop clean.
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Fresh basil leaves top a warm Mozzarella Pesto Chicken Grilled Cheese, served neatly sliced alongside a bowl of marinara. Pin this
Fresh basil leaves top a warm Mozzarella Pesto Chicken Grilled Cheese, served neatly sliced alongside a bowl of marinara. | platesignal.com

Hope this sandwich finds you on a day when you need exactly this much comfort.

Recipe Questions

Can I use different bread for this sandwich?

Absolutely. While sourdough and Italian bread work wonderfully, try ciabatta for a lighter crumb or multigrain for added texture and nutrition. Adjust cooking time slightly if using thicker bread.

What's the best way to shred chicken for this?

Use rotisserie chicken for convenience and flavor. Simply pull the meat apart with two forks. Alternatively, poach or grill chicken breasts, then shred. Ensure chicken is fully cooked and slightly warm before assembling.

How do I prevent the bread from burning while the cheese melts?

Keep heat at medium, not high. Cook for 3-4 minutes per side, pressing gently with a spatula. This allows even browning and proper cheese melting. Lower heat slightly if bread colors too quickly.

Can I make this vegetarian?

Yes. Replace chicken with grilled vegetables like zucchini, roasted peppers, or eggplant. You can also add spinach or arugula for extra greens. The pesto and mozzarella provide plenty of flavor.

What should I serve alongside this sandwich?

Pair with crisp Italian white wine, sparkling water with lemon, or a light salad. Tomato soup complements the pesto and cheese beautifully for a classic pairing.

Can I make pesto from scratch?

Definitely. Blend fresh basil, garlic, pine nuts, Parmesan, olive oil, and lemon juice. Homemade pesto offers brighter flavor than store-bought. Make it ahead and refrigerate for up to one week.

Mozzarella Pesto Chicken Grilled Cheese

Golden grilled cheese featuring shredded chicken, basil pesto, and melted mozzarella. Ready in 20 minutes for two servings.

Prep time
10 min
Cook time
10 min
Total duration
20 min
Created by Carson Hughes


Skill level Easy

Cuisine American/Italian Fusion

Yields 2 Portions

Dietary notes None specified

What You Need

Bread & Dairy

01 4 slices sourdough or Italian bread
02 4 oz fresh mozzarella, sliced or shredded
03 2 tbsp unsalted butter, softened

Protein

01 1 cup cooked, shredded chicken breast

Sauces & Spreads

01 3 tbsp basil pesto

Optional Add-Ins

01 2 tbsp grated Parmesan cheese
02 1 small tomato, thinly sliced
03 Fresh basil leaves

How to Make It

Step 01

Prepare bread slices: Lay out the bread slices and spread 1 to 1.5 tbsp pesto onto two of the slices.

Step 02

Layer chicken: Evenly distribute the shredded chicken on top of the pesto-covered slices.

Step 03

Add cheese and toppings: Layer mozzarella cheese over the chicken. Add tomato slices and fresh basil if using. Sprinkle with Parmesan for extra flavor, if desired.

Step 04

Assemble sandwiches: Top with the remaining bread slices to form sandwiches.

Step 05

Butter exterior: Spread the softened butter on the outsides of each sandwich, covering both top and bottom surfaces.

Step 06

Cook sandwiches: Heat a large skillet or grill pan over medium heat. Place the sandwiches in the skillet, pressing them slightly with a spatula. Cook for 3 to 4 minutes per side, or until the bread is golden brown and the cheese is melted.

Step 07

Finish and serve: Remove from the skillet, let rest for 1 minute, then cut in half and serve warm.

What You'll Need

  • Skillet or grill pan
  • Spatula
  • Knife
  • Cutting board

Allergy details

Please review each ingredient for possible allergens. Check with a health specialist if uncertain.
  • Contains dairy: mozzarella, butter, Parmesan cheese
  • Contains wheat and gluten from bread
  • May contain tree nuts if pesto contains pine nuts
  • Check store-bought pesto labels for additional nut and cheese allergens

Nutrition info (per serving)

These nutrition stats are for general info and not a substitute for professional advice.
  • Calories: 520
  • Total fat: 27 g
  • Carbohydrates: 32 g
  • Proteins: 36 g